Gluma is a desensitizing chemistry for treating and preventing dentinal hypersensitivity. Gluma patented (Heraeus Kulzer) glutaraldehyde/HEMA (2-hydroxyethyl methacrylate) formula acts in seconds to seal dentinal tubules, preventing the fluid shifting recognized as the primary cause of localized hypersensitivity. Gluma also inhibits the growth of bacteria, which are also indicated as a cause of sensitivity. Gluma patented formula works within the dentinal tubule complex by reacting with protein fluids to form a physiological seal within the tubules. No surface layer is formed, making Gluma ideal for use under all indirect restorations.